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A Novel icIEF Fractionation and SPR-Based Workflow for Correlating the Charge Structure to the Function of a Bispecific Antibody
Overview This application note presents a novel and efficient method for determining binding kinetic...
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Analysis of HIS-tagged ligands on Alto digital SPR using an anti-HIS capture sensor
Overview Nicoya’s Anti-HIS Capture Kit gives users the ability to capture histidine-tagged (HIS-ta...
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Analysis of biotin-tagged proteins on Alto digital SPR using a streptavidin functionalized sensor
Overview Nicoya’s Streptavidin Kit allows users to irreversibly capture biotinylated ligands direc...
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Rapid, automated capture screening of influenza antiviral targets using Nicoya Alto® digital surface plasmon resonance
Overview Rapid screening and kinetic characterization of medium sized libraries is commonly seen as ...
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Characterization of HuCAL Fab-MH binding kinetics on Alto™ digital surface plasmon resonance using a Twin-Strep-tag® capture system
Overview In this application note, Alto™ digital SPR was used to characterize HuCAL Fab-MH kinetic...
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Accelerating influenza antibody therapeutics with Alto™ digital microfluidic-powered epitope binning and kinetics analysis
Overview Annual formulation updates for influenza vaccines and related antibody therapies are requir...
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Label-free characterization of transmembrane proteins using Alto™ digital SPR
Overview Many human diseases are known to be associated with transmembrane proteins (TPs), making th...
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Characterization of Alto™ Sample Preparation Precision and Accuracy Enabled by DMF
Overview Precise and accurate liquid handling is crucial to obtaining repeatable, high-quality data ...
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Epitope Characterization of Influenza Antiviral Targets Using Alto™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloak...
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Characterization of Complementary Oligonucleotide Sequences using Alto™
Overview Oligonucleotides offer a promising vector for the treatment of diseases related to gene exp...
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Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologic...
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Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and inte...
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Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have sub...
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Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of ...
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Kinetic and Epitope Characterization of Influenza Antiviral Targets Using Alto™ Digital Surface Plasmon Resonance
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloak...
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Protein A – IgG Interaction Analysis Using Alto™
Alto™ is a high-throughput benchtop surface plasmon resonance (SPR) instrument providing detailed ...