Poster: Characterization of Therapeutic Antibodies using Digital SPR


Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors. With simultaneous detection across 16-channels, Alto provides high-throughput analysis of up to 48 unique targets, while further streamlining user workflows with automated sample dilutions, disposable fluidics, and sample requirements reduced by up to 200X. In collaboration with Sino Biological, a global leader in research reagents, we demonstrate how Alto is an ideal platform for therapeutics development through crude library screening, binding kinetics characterization, and epitope binning of Sino Biological’s influenza products.

Heat map of 16×16 epitope binning of anti-HA antibodies against the HA antigen, with blue indicating ‘bind’.