Characterization of Complementary Oligonucleotide Sequences using Alto™


Oligonucleotides offer a promising vector for the treatment of diseases related to gene expression and have recently transformed the vaccine industry with the resounding success of mRNA-based COVID-19 vaccines. In this application note, we demonstrate Alto’s applicability to the development of oligonucleotide systems in various therapeutic capacities. Alto is used to accurately and precisely measure affinities and provide on/off-rates equivalent to those obtained with conventional SPR.

Overview of Nicoya oligo system.