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Poster: Characterization of Therapeutic Antibodies using Digital SPR
Overview Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors. With simultaneous detection across 16-channels, Alto provides high-th...
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Screening of Unknown Antibodies in Complex Media with Alto™ Digital SPR
Overview Screening is a common tool used to quickly test activity of a large number of chemical or biological compounds. Commonly seen as one of the first steps within the drug discovery process, scre...
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Characterization of biosimilars derived from PlantForm’s vivoXPRESS® technology with Alto™ Digital SPR
Overview Biological drugs, or biologics, have transformed patient outcomes worldwide due to their ability to treat diseases with a higher degree of precision and specificity compared to small-molecule...
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Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA a...
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Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated hosts. Hence, annual formulation upd...
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Characterization of Complementary Oligonucleotide Sequences using Alto™
Overview Oligonucleotides offer a promising vector for the treatment of diseases related to gene expression and have recently transformed the vaccine industry with the resounding success of mRNA-based...
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Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of the modern biologics res...
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Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments due to the vast number of ...
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Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation of cancer immunotherapy. In this a...
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Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of sample...
