Blog
Educational material, comparison studies and publications on SPR and other related techniques for researchers.
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OpenSPR Binding Data Uncovers Virulence Mechanism of Streptococcus pyogenes
Virulence factors are tools employed by pathogenic organisms to utilize, evade, colonize, suppress or destroy normal immune responses in a host. An example of a virulence factor is lipid A, a component of endotoxins produced by gram-negative bacteria, such as E. coli. In the context of treating pathogenic infections, virulence factors are the primary targets […]
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Pros & Cons of Fluorescence-Based Binding Assays
As the availability of affordable technology increases, reviewers are constantly requesting binding data during the publishing process. However, measuring only affinity or obtaining simplistic yes/no binding data may not satisfy all the requirements you need to successfully publish your research. There are many techniques that dig deeper beneath the surface than just affinity, including fluorescence […]
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How SPR Fits in Your Interaction Research Workflow
Trends in Publications How do you measure success as an academic researcher? Although there are many paths that a scientific research project takes, the end goal remains the same; publishing your work. Our mission at Nicoya is to help researchers publish faster with high-quality quantitative binding data. As the availability of affordable technology increases, reviewers […]
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Advancing Neuromuscular Disease Research with OpenSPR Binding Data
The human nervous system is a complex collection of over 100 billion nerve cells that regulate countless processes within the body. Within the processes of the muscular system, nerve and muscle cells are united with the neuromuscular junction (NMJ), playing a vital role in the development of neuromuscular diseases. The NMJ is also responsible for […]
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OpenSPR Binding Data Advances Delivery Method of Photodynamic Cancer Therapeutics
Dr. Xiaofeng Liu recently published a paper using binding data generated from OpenSPR to reveal an effective affibody-based photosensitizer carrier used in Photodynamic Therapy (PDT), a less invasive alternative to cancer treatments. Read the full article to see how OpenSPR provided Dr. Xiaofeng Liu with the key binding data needed to advance PDT.
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OpenSPR-XT Binding Data Opens New Doors for Targeting of RNA Binding Proteins for Glioblastoma Therapeutics
Dr. Luis Penalva recently published a paper using binding data generated from the OpenSPR-XT’s automated SPR technology assessing the effectiveness of luteolin binding to RNA binding protein, Msi1. Read the full article to see how OpenSPR-XT provided Dr. Penalva with the key binding data needed for his latest discovery of an effective glioblastoma treatment.
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Discovery of a Gene Regulation Network in P. aeruginosa Biofilm Production using OpenSPR Binding Data
Dr. Tung T. Hoang recently published a paper using binding data generated from OpenSPR to quantify the formation of a stable complex between 2 co-regulators of biofilm production and their target DNA binding sequence. Read the full article to see how OpenSPR provided Dr. Hoang with the key binding data needed to authenticate a gene regulation network in P. aeruginosa biofilm production.
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The OpenSPR Centre of Excellence – Building a Community of Innovative Researchers in India & Beyond
Dr. Ramaswamy (Dr. Rams) is a leading scientist in India with over 100 publications to date. In collaboration with Dr. Rams and his lab, Nicoya hosted the grand opening of the “OpenSPR Centre of Excellence” at the Institute for Stem Cell Biology and Regenerative Medicine in Bangalore, India.
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OpenSPR Binding Data Advances Peptide Screening Methods
Dr. Leonard Luyt recently published a paper using binding data generated from the OpenSPR to quantify the binding behaviour of a chemically synthesized 7 kDa RHAMM “mini-protein” engineered for screening of candidate therapeutic peptides. Read the full article to see how OpenSPR provided Dr. Luyt with the key binding data needed for his latest advancement on therapeutic peptide screening methods.
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OpenSPR Binding Data Advances Targeting Potential of Anti-Cancer Therapeutics
Dr. Huile Gao recently published a paper that unveils how protein corona formation may significantly reduce the interaction potential of ligand-modified PNs to target TfR, a common target for anti-cancer therapeutics. Read the full article to see how OpenSPR binding data provided Dr. Huile Gao insight into enhancing drug delivery methods for anti-cancer therapeutics.