Blog
Educational material, comparison studies and publications on SPR and other related techniques for researchers.
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Expanding to Boston and beyond: Meet the team behind our new lab facility
We’re proud to announce the opening of our new lab facility in Boston! Read on to learn about the expansion of our services to accelerate drug discovery in Greater Boston and beyond. It has already proven to be a year of milestones at Nicoya, with the acquisition of LSK Technologies and being named Life Science […]
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Conventional vs Digital SPR: Comparing label-free tools for biologics discovery and development
In this blog, we break down the difference between conventional and digital surface plasmon resonance (SPR) systems to help you select the right solution for your lab. Introduction Biomolecular interactions are often at the heart of therapeutic discovery as they promote the regulation and execution of most biological processes in the body. Thus, early drug […]
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What’s in store for 2022? Announcing our $20M Series A Extension
Equipping biologics researchers with disruptive tools in the era of proteomics Ryan Denomme, Co-founder and CEO At Nicoya, we build proteomics tools to provide researchers with powerful insights while alleviating the notorious challenges of traditional instrument platforms. Our first product, OpenSPR™, was inspired by my personal frustration with the inaccessibility of SPR technology during my […]
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The role of SPR in immunotherapeutic research
Read on to learn about the insights that Surface Plasmon Resonance (SPR) can provide for immunotherapeutic research. Introduction According to John Hopkins Medicine, almost 40 percent of the population of the United States will be diagnosed with cancer during their lifetime. Despite this staggering statistic, the advancements being made in cancer research and treatments have […]
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Analyzing binding kinetics: Which method is best for your next SPR experiment?
Read on to learn about the two most common approaches for measuring binding kinetics, multi-cycle kinetics (MCK) and single-cycle kinetics (SCK), and how to select the right one for your interaction.
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Nicoya receives over $1.9M in funding to continue the development of a portable, saliva-based COVID-19 test
The arrival of COVID-19 vaccines has tipped the scale in favor of winning the battle against the pandemic, but the war is far from over. Diagnostic tests, along with vaccines, are required to stop outbreaks and end the pandemic, as these tests are key to identifying potential infection vectors. As we move toward gaining normalcy […]
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Cryo-EM and SPR: Complementary technologies providing structural and functional insights toward advancing coronavirus research
How did two cutting-edge technologies ultimately enable researchers to develop COVID-19 vaccines at an unprecedented rate? The development of COVID-19 vaccines is a seminal discovery of this decade. The most remarkable feature of this achievement was the unprecedented rate at which the vaccines were developed. A major time-consuming bottleneck in vaccine development is the identification […]
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4 Ways To Reduce Non-specific Binding in Surface Plasmon Resonance Experiments
Improve the quality of your SPR data with these optimization strategies If you aren’t familiar with Surface Plasmon Resonance (SPR),check out our article on What is SPR? before continuing. What is non-specific binding? During an SPR experiment, there are many experimental parameters that must be controlled in order to optimize the performance of the system […]
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OpenSPR Binding Data Reveals a Potential Mechanism for the Treatment of Depression
Introduction Depression is becoming more and more common worldwide, with approximately 1 in 30 people being affected by the illness[1]. Resulting from a combination of genetic, social and psychological factors, depression impacts one’s quality of living and can range in severity, from affecting their motivation for daily tasks to being completely debilitating. Modern medicine’s impact […]
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Surface Plasmon Resonance Sensors: A Comprehensive Guide for Scientists
Getting ready to plan for your surface plasmon resonance (SPR) experiments? Great! So, you probably already know the value of using SPR technology and how it is becoming more affordable and accessible for researchers everywhere. We believe that SPR will become a standard technique available in every biochemistry lab. If you have yet to discover the advantages of surface plasmon resonance, visit our blog post 6 advantages of surface plasmon resonance. The first step in planning for your SPR experiment is to determine which type of SPR sensor chip is right for your application. The type of sensor chip required depends on your ligand, which needs to be immobilized to the sensor chip before you can measure the interaction between your ligand and analyte. There are two categories – covalent or capture coupling-based sensor chips. Today, you will learn the differences between the two and the advantages and disadvantages associated with both.