Small Molecule Interactions

Quantitatively characterize your interaction with binding kinetics & affinity data. 

Protein_smalMol

Protein-Small Molecule

Ligand: CAII protein immobilized onto a High Sensitivity Carboxyl Sensor

Analyte: Furosemide (330 Da)

kon = 1.42×104 M-1 s-1

koff = 6.6×10-2 s-1

KD = 0.430 mM

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Outcomes:

  • Determine kon and koff (kinetics) and
  • KD (affinity) values
  • Yes/No Binding
  • Determine inhibition
  • Specificity
  • Ranking and screening

Use Cases:

  • Drug discovery
  • Small molecule development
  • Expressed protein interactions
  • Isolated/extracted protein interactions
  • Screening for ligand binding partners

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OpenSPR-Instrument

Overview

OpenSPR is the world’s only benchtop surface plasmon resonance (SPR) instrument. It provides high quality, label-free interaction analysis for a fraction of the cost of existing solutions. Our unique nano-structured sensor surface uses localized SPR (LSPR) to deliver repeatable, highly sensitive kinetic data.

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