Blog
Educational material, comparison studies and publications on SPR and other related techniques for researchers.
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2022 wrapped: Celebrating 10 years at Nicoya
We took a moment to look back on the key events that shaped this milestone year. By Ryan Denomme, Co-Founder and CEO Quick links A year of milestones What’s new for our users? Learnings from the field The road ahead As another whirlwind year comes to an end, I have yet to fully grasp that […]
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SPR vs BLI: Comparing label-free tools for Fc receptor characterization
Alto™ streamlines the characterization of Fc gamma receptors in our latest app note comparing analysis with Digital SPR and BLI. Fc receptors (FcR), named for their binding specificity to the fragment crystallizable region of antibodies, play a key role in myriad biologic pathways. As FcR dysregulation is implicated in a wide range of autoimmune disorders, […]
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New Nature study reveals insights into de novo autoreactivity in severe COVID-19 using Alto™ Digital SPR
Kinetic analysis of de novo autoreactivity in severe COVID-19 reveals important implications for early intervention and treatment in patients with post-COVID sequelae. The SARS-CoV-2 outbreak was first declared a Public Health Emergency of International Concern by the World Health Organization (WHO) on January 30, 2020, and upgraded to pandemic status just five weeks later.1 This […]
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Targeting interleukins: How digital SPR accelerates monoclonal antibodies for immune-related diseases
Alto’s unmatched ability to seamlessly characterize mAbs make it the optimal fit for biologics developers. Read our latest application note on digital SPR analysis of the interleukin-6 receptor (IL-6R) to learn more. A decade after it was first introduced to the market, the drug tocilizumab gained attention once again in 2021 for being issued emergency […]
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Cancer detection using SPR: Announcing our partnership with INOVIQ
The SubB2M™-based SPR test will detect for pan-cancer biomarker Neu5Gc in blood samples on Alto™, and will initially be used as a cancer risk assessment test. We’re excited to announce our partnership with Australian diagnostics leader INOVIQ to develop a surface plasmon resonance (SPR) based cancer risk assessment test. Leveraging INOVIQ’s SubB2M™ cancer detection technology, […]
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Application note: Characterization of ImmTAC® bispecific molecules with Alto™ digital SPR
Immunocore’s ImmTAC technology is a novel class of biologics that target cancer cells through T-cell redirecting immunotherapy. Bispecific molecules, or bispecifics, are a growing subset of biotherapeutics that offer a promising new modality for the treatment of a wide range diseases. Due to their ability to bind to multiple targets and to offer diverse modes […]
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Conventional vs Digital SPR: Comparing label-free tools for biologics discovery and development
In this blog, we break down the difference between conventional and digital surface plasmon resonance (SPR) systems to help you select the right solution for your lab. Introduction Biomolecular interactions are often at the heart of therapeutic discovery as they promote the regulation and execution of most biological processes in the body. Thus, early drug […]
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What’s in store for 2022? Announcing our $20M Series A Extension
Equipping biologics researchers with disruptive tools in the era of proteomics Ryan Denomme, Co-founder and CEO At Nicoya, we build proteomics tools to provide researchers with powerful insights while alleviating the notorious challenges of traditional instrument platforms. Our first product, OpenSPR™, was inspired by my personal frustration with the inaccessibility of SPR technology during my […]
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The role of SPR in immunotherapeutic research
Read on to learn about the insights that Surface Plasmon Resonance (SPR) can provide for immunotherapeutic research. Introduction According to John Hopkins Medicine, almost 40 percent of the population of the United States will be diagnosed with cancer during their lifetime. Despite this staggering statistic, the advancements being made in cancer research and treatments have […]
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Analyzing binding kinetics: Which method is best for your next SPR experiment?
Read on to learn about the two most common approaches for measuring binding kinetics, multi-cycle kinetics (MCK) and single-cycle kinetics (SCK), and how to select the right one for your interaction.