Application Notes

Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI

Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of the modern biologics res...

Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™

Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments due to the vast number of ...

Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™

Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation of cancer immunotherapy. In this a...

Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR

Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of sample...

Kinetic and Epitope Characterization of Influenza Antiviral Targets Using Alto™ Digital Surface Plasmon Resonance

Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated hosts. Hence, annual formulation upd...

Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™

Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COVID-19. This includes basic research for understanding the viral infection mechanisms, the developmen...

Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™

Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemble a specific virus without its genetic material. VLPs are frequently used to study viruses without ...

Protein A – IgG Interaction Analysis Using Alto™

Alto™ is a high-throughput benchtop surface plasmon resonance (SPR) instrument providing detailed binding kinetics and affinity data for a wide variety of molecular interactions. Alto™ uses digita...

Binding Kinetics of an Antibody Serum Sample Using OpenSPR™

A common application of the SPR technique is antibody screening, which is critical to the development of vaccines and other immunotherapies. Since this development often involves screening animal sera...

Comparison Study of Label-Free Biosensors Using Commercially Relevant Binding Systems

Overview The OpenSPR™ is a powerful instrument providing researchers with in-depth label-free binding kinetics for a variety of different molecular interactions. A side by side comparison study was ...