Application Notes

Poster: Characterization of Therapeutic Antibodies using Digital SPR

Overview Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors. With simultaneous detection across 16-channels, Alto provides high-th...

Screening of Unknown Antibodies in Complex Media with Alto™ Digital SPR

Overview Screening is a common tool used to quickly test activity of a large number of chemical or biological compounds. Commonly seen as one of the first steps within the drug discovery process, scre...

Characterization of biosimilars derived from PlantForm’s vivoXPRESS® technology with Alto™ Digital SPR

Overview Biological drugs, or biologics, have transformed patient outcomes worldwide due to their ability to treat diseases with a higher degree of precision and specificity compared to small-molecule...

Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™

Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA a...

Epitope Characterization of Influenza Targets using OpenSPR™

Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated hosts. Hence, annual formulation upd...

Characterization of Complementary Oligonucleotide Sequences using Alto

Overview Oligonucleotides hold great potential for treating diseases linked to gene expression and have recently revolutionized the vaccine industry with the remarkable success of mRNA-based COVID-19 ...

Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI

Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of the modern biologics res...

Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™

Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments due to the vast number of ...

Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™

Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation of cancer immunotherapy. In this a...

Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR

Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of sample...