Resources
Using Circular Dichroism to Quantitatively Compare the Higher Order Structure of Protein Biologics
Presenter: John Garrison Vice President, Analytical Sciences and Site Head Elion Labs KBI Biopharma Overview In this webinar, Dr. Garrison explores how CD is used…
Mechanisms For Aggregation And Stabilisation
Presenter: John Carpenter Professor Emeritus University of Colorado Anschutz Medical Campus Overview In this webinar, John Carpenter shares his expertise on the stability of biopharmaceuticals.…
Characterisation and control strategy for an ADC
Presenter: Jesse Coe Associate Director of Business Development KBI Biopharma Overview In this webinar, Jesse explores the complexities of product characterisation and control strategy, focusing…
Breakthrough CD & FTIR analysis for mAbs, ADCs and AAV’s
Presenter: Rina Dukor President and Co-Founder BioTools INC Overview Rina, President and Co-Founder at BioTools INC, explores how spectroscopy techniques like circular dichroism (CD), Fourier-transform…
How to identify and quantify Adeno-Associated Virus fill states using analytical ultracentrifugation
Presenter: Karl Maluf Director of the Biophysical Characterisation Core KBI Biopharma Overview In this talk, Karl discusses the challenges of analysing AAV heterogeneity and the…
Chirascan Platform Brochure
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SX20 Consumables & Accessories Brochure
Learn more about the consumables and accessories for SX20
SX20 Brochure
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SUPR-DSF Brochure
Learn more about SUPR-DSF
Multi-method Benchtop Analyses To Gain Novel Insight Into Structure And Internal Stability Of Lipid Nanoparticles For mRNA Delivery
Overview This application note demonstrates how circular dichroism spectroscopy and differential scanning calorimetry can be used together to investigate the structure and thermal stability of…
Rational Optimization of Solvent Conditions for G-Quadruplex Oligonucleotides
Overview As the regulatory role of G-quadruplex structures in crucial biological processes emerges, CD spectroscopy can be expected to gain increased importance in their characterization…
Secondary Structure and Stability of Imperfect G-Quadruplex Oligonucleotides
Overview G-quadruplexes (GQs) are important biomarkers and drug targets because of their regulatory role in transcription. Adherence to the GQ consensus sequence is often used…
Far-UV CD Analysis During Biotherapeutic Development: A Method Capability Study
Overview In this study carried out by Novartis, far- UV CD spectroscopy was qualified for the early development of a monoclonal antibody therapeutic. The high…
Determination of Species-Specific Rate Constants of the Reaction Between Ferrate(VI) and Sulfonamide Antibiotics
Overview Applied Photophysics SX20 stopped-flow spectrometer can be used to study the species-specific rate constants of the reactions between FeVI and SAs. Values of k…
Shining Light on Non-Chemical Steps in Protein Catalysis
Overview Stopped-flow experiments using Applied Photophysics SX20 and Chirascan V100 SF.3 systems allow monitoring of different spectral properties including fluorescence, absorbance, and even far-and near-UV…
High Sensitivity Direct Mount Photodiode Array for the SX20
Overview The directly mounted photodiode array accessory ensures highly efficient light collection for stopped-flow absorbance measurements. The improved design ensures that ultimate sensitivity is achieved…
Stopped-Flow Fluorescence (Förster) Resonance Energy Transfer (FRET)
Overview Stopped-flow FRET is a useful technique for studying many types of biomolecular interactions. The method provides kinetic information regarding distance changes occurring on the…
Identification of AAV Serotypes and Characterisation of their Stability by DSF for use in a Gene Therapy Program
Overview In this application note we used the SUPR-DSF to measure the thermal stability of three AAV serotypes: AAV2, AAV5, and AAV6. The SUPR-DSF measured…
