Presenter:
John Carpenter
Professor Emeritus
University of Colorado Anschutz Medical Campus
Overview
In this webinar, John Carpenter shares his expertise on the stability of biopharmaceuticals. He focuses on the role of formulation, storage, and manufacturing processes in maintaining drug efficacy and explores how analytical techniques provide insights into protein stability, aggregation, and degradation pathways. Biopharmaceuticals, including monoclonal antibodies and therapeutic proteins, require precise formulation strategies to prevent instability and ensure therapeutic effectiveness. John’s research illuminates the mechanisms driving protein aggregation and the impact of excipients, temperature, and stress conditions on stability.
Key Insights:
- Mechanisms of Protein Aggregation: Understanding the factors influencing protein misfolding and aggregation in therapeutic formulations.
- Impact of Excipients: How stabilising agents like polysorbates and sugars affect protein stability and prevent degradation.
- Analytical Approaches: The role of biophysical techniques in assessing protein conformation and predicting long-term stability.
Impact and Future Directions:
- Strategies for improving biopharmaceutical formulation to enhance shelf-life and therapeutic performance.
- The evolving landscape of analytical characterisation for regulatory approval and quality control.
Discover how John Carpenter’s work continues to shape best practices in biopharmaceutical development, ensuring safe and effective therapeutic proteins for patients worldwide.
