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The ABC’s of Competitive Binding Assays with SPR
In the arena of drug discovery, there are a number of tools available for researcher’s to characterize binding behaviours of low molecular weight compounds with their target(s). These tools may incl...
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OpenSPR Binding Data Uncovers Antipsychotic Drug Mechanisms
Over the last number of years, there’s been an increasing amount of attention on combating mental illness and the associated stigma. Notably, psychiatric counseling is an important facet of treatmen...
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Technical Guide: Binding Assays with Flow Cytometry and SPR
Flow cytometers are excellent tools for the modern cell biologist and immunologist. They can provide a wide range of information which help researchers discern various cellular physical and chemical c...
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Preparing for Publication: Identification and Characterization
In our previous blog post, we explored some of the most commonly used structures for expression and purification of your protein binding partners. The expression systems we addressed included bacteria...
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Preparing for Characterization: Expression and Purification
When proposing a research project, there’s a number of project steps that require advanced planning. Asking questions like, “do I need to express and purify any protein(s)?”, and accounting for ...
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SPR Tips: 3 Ways To Limit Mass Transfer Effects In Kinetic Data
In surface plasmon resonance, the reactant in a solution must first diffuse from the bulk to the surface to interact with the immobilized ligand. If the diffusion rate is slower than the association r...
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How to Become a Surface Plasmon Resonance Superhero: Top 5 Things We Learned at SensorCon 2015
SensorCon One was a 4 day intensive training course/conference hosted in Salt Lake City, UT by David Myszka and Rebecca Rich of Biosensor Tools. They are both leaders in the field of label-free analys...