Accelerate your drug discovery with the world’s first digital, high-throughput, benchtop SPR system

Meet Alto

Industry Leading Data Quality


High-Throughput Powered by Automation



Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors.

DMF technology enables all fluidics to be disposable, allowing for precise handling of 2µL sample volumes, crude sample compatibility and zero fluidics maintenance. Alto’s compatibility with automation for both hardware and software provides sample-in/answer-out data, industry-leading throughput, and 24+ hours of unattended run time.

Every aspect of Alto is designed with user-friendliness and accessibility in mind-from the flexible 16 channel design to the intuitive data analysis platform.

The first ever DMF-powered SPR system

Alto cartridges have completely revolutionized the interaction of fluidics and SPR sensors by integrating them into one disposable microwell plate.

Compatible With
Surface Chemistries
Digital Microfluidics Close Up

Advantages of using DMF-powered SPR

  • Decoupling of flow rate and sensor position from dispersion, increasing data quality


  • Up to 200X less sample volume required – get full kinetics from a 2µL sample volume


  • Decoupling of interaction time from sample volume, increasing assay flexibility


  • Automated serial dilutions – reducing human error and saving time

Software designed for any skill level

Alto’s comprehensive software, the Nicosystem, provides a centralized hub for acquisition and analysis of real-time binding data, while offering you the flexibility of accessing and sharing your experiments from anywhere.

Explore Nicosystem options for your research needs and budget today.

Screenshot of sample loading screen on the Alto Digital SPR software

Product Selection Guide

Accelerate your next discovery with our benchtop SPR solutions. Read our guide to learn which system is right for your lab. 

Technical Specifications

Performance Association Rate (kon), Up to 1x10⁹ 1/M*s Dissociation Rate (koff), 1x10⁻⁵–1.0 1/s Affinity Range (KD), pM - mM
Hardware Core Detection Technology, Localized SPR fiber optic biosensors Data Channels, 16 Analytes, Up to 48 analytes/cartridge Sample Volume, 2μL Reference:Standard, 1:1 Dilutions, Automated serial dilutions Unattended Run Time, 24+ hours Compliance, Please inquire for your specific needs Instrument Size, 1.5H x 1W x 1.5D (ft) Instrument Weight , 51 lbs

Ready to accelerate your drug discovery with Alto?