Alto

Accelerate your drug discovery with the world’s first digital, high-throughput, benchtop SPR system

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Industry Leading Data Quality

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High-Throughput Powered by Automation

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Overview

Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors.

DMF technology enables all fluidics to be disposable, allowing for precise handling of 2µL sample volumes, crude sample compatibility and zero fluidics maintenance. Alto’s compatibility with automation for both hardware and software provides sample-in/answer-out data, industry-leading throughput, and 24+ hours of unattended run time.

Every aspect of Alto is designed with user-friendliness and accessibility in mind-from the flexible 16 channel design to the intuitive data analysis platform.

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The first ever DMF-powered SPR system

Alto cartridges have completely revolutionized the interaction of fluidics and SPR sensors by integrating them into one disposable microwell plate.

Applications
  • Kinetics/Affinity Characterization
  • Kinetics/Affinity Screening
  • Quantitation
  • Epitope Mapping/Binning
APPLICATION NOTE
Compatible With
  • Proteins / Peptides
  • Antibodies
  • Nucleic Acids
  • Carbohydrates
  • Crude samples
  • Viruses
  • Small Molecules (application dependent)
Surface Chemistries
  • Carboxyl
  • Anti-His (kit)
  • Streptavidin (kit)
  • Protein A (kit)
Digital Microfluidics Close Up

Advantages of using DMF-powered SPR

  • Decoupling of flow rate and sensor position from dispersion, increasing data quality

     

  • Up to 200X less sample volume required – get full kinetics from a 2µL sample volume

     

  • Decoupling of interaction time from sample volume, increasing assay flexibility

     

  • Automated serial dilutions – reducing human error and saving time
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Software designed for any skill level

Alto’s comprehensive software, the Nicosystem, provides a centralized hub for acquisition and analysis of real-time binding data, while offering you the flexibility of accessing and sharing your experiments from anywhere.

Explore Nicosystem options for your research needs and budget today.

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Screenshot of sample loading screen on the Alto Digital SPR software

Alto GxP Suite

The Alto GxP Suite includes a software expansion and services to support regulated labs in meeting strict compliance requirements, including FDA’s 21 CFR Part 11 guidelines. 

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Alto Lab Catalyst Program

Are you an academic PI starting a lab or an early-stage biotech startup? The Alto Lab Catalyst Program is designed to empower you by providing affordable access to Alto digital SPR technology and dedicated support.

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Zoomed in Alto cartridge loaded into the instrument
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final alto image.optimized

Technical Specifications

Performance
Association Rate (kon) Up to 1x10⁹ 1/M*s
Dissociation Rate (koff) 1x10⁻⁵–1.0 1/s
Affinity Range (KD) pM - mM
Hardware
Core Detection Technology Localized SPR fiber optic biosensors
Data Channels 16
Analytes Up to 48 analytes/cartridge
Sample Volume 2μL
Reference:Standard 1:1
Dilutions Automated serial dilutions
Unattended Run Time 24+ hours
Compliance Please inquire for your specific needs
Instrument Size 1.5H x 1W x 1.5D (ft)
Instrument Weight 51 lbs

Ready to accelerate your drug discovery with Alto?

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B-29 King Street East
Kitchener, ON, Canada
N2G 2K4

1.877.673.6777

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