Understanding cytokine-receptor interactions is critical for advancing immunology research and therapeutic development, but capturing these interactions in a native-like state can be challenging.
In this webinar, Conigen Bioscience’s Assay Development Scientist, Dr. Alyssa Ball will share how they leveraged Nicoya’s Alto digital surface plasmon resonance (SPR) system to characterize the binding kinetics of several homo- and heterodimeric cytokine receptors, including human Type II interferon γ receptor 1 (IFNγR1) and human Type I interferon α receptor (IFNαR).
By mimicking the natural dimeric conformations of cytokine receptors, the team achieved significantly enhanced binding potency to their respective cytokines (IFNγ and IFNα) – insights made possible by Alto’s real-time, label-free analysis in a high-throughput, digital format.
Topics covered
Useful resources are linked below.
As the world’s only surface plasmon resonance (SPR) system powered by digital microfluidics, Alto™ revolutionizes real-time interaction analysis by eliminating the need to compromise on quality and time. Go from sample to answer within hours while streamlining even the toughest of biologics applications with Alto’s intuitive and automated ecosystem. Designed to take the complexity out of SPR, Alto™ will empower your team with the data they need to take their discoveries to the next level.
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Alto’s comprehensive software, the Nicosystem, provides a one-stop centralized hub for acquisition and analysis of real-time binding data, all while offering an intuitive user interface, one-click analysis feature, and the flexibility of accessing your experiments from anywhere.
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