Webinar On Demand

Digital SPR (dSPR) is a next-generation technology for characterizing biomolecular interactions. By combining digital microfluidics (DMF) with localized SPR (LSPR), digital SPR systems can effectively bypass common challenges found in traditional SPR and BLI platforms.

Understanding drug mechanisms in complex systems, particularly in the brain, remains challenging despite advancements at the molecular level Yet, cell-specific technologies like DART provide a promising solution, enabling targeted drug delivery to genetically defined neuronal cell types, thereby allowing the observation of the drug effects on brain dynamics and animal behavior. (Shields et al., bioRxiv, 2022, Shields et al., Science, 2017).

The underlying principle of DART technology is the covalent interaction between a protein and its target chemical molecule. In this webinar, we will discuss the optimization of the covalent capture affinity of DART, and the subsequent functional analysis of binding kinetics, using dSPR.

What You Will Learn:

• What digital SPR is and how it works.
• See how data quality and throughput are maximized using the latest advances in digital SPR to eliminate artifacts, optimize accuracy, and automate tedious, error-prone sample preps.
• See how researchers at Duke University utilize this technology to rapidly assess the binding kinetics of a covalent interaction between a biological ligand and its chemical analyte.