Small Molecule Interactions
Quantitatively characterize your interaction with binding kinetics & affinity data. *Application dependent.Â
Protein-Small Molecule
Ligand: Msi1 RBD1 immobilized on COOH sensor chip
Analyte: Luteolin (286 Da)
kon = ~ 6.16 X 103 ± 42 M−1s−1
koff = ~ 1.97 X 10−2 ± 2.93 X 10−7 s−1
KD = ~ 3.2 ± 0.02μM
Outcomes:
- Determine kon and koff (kinetics) and
- KD (affinity) values
- Yes/No Binding
- Determine inhibition
- Specificity
- Ranking and screening
Use Cases:
- Drug discovery
- Small molecule development
- Expressed protein interactions
- Isolated/extracted protein interactions
- Screening for ligand binding partners
See OpenSPR in Action
Discuss your workflows with an application scientist & see how benchtop SPR can help.
Overview
OpenSPR is the world’s only benchtop surface plasmon resonance (SPR) instrument. It provides high quality, label-free interaction analysis for a fraction of the cost of existing solutions. Our unique nano-structured sensor surface uses localized SPR (LSPR) to deliver repeatable, highly sensitive kinetic data.
Make your next scientific breakthrough with OpenSPR.
Discuss your research applications with an SPR application scientist: