Resources
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using a Human/rabbit IgG VHH capture reagent
Nicoya’s Protein A Capture Kit allows users to capture antibodies or Fc-tagged proteins directionally, offering an optimal orientation for analyte binding. This method also enables…
Nicoya Brochure
Explore the full Nicoya portfolio, including Alto and Revo digital SPR, Chirascan CD, OpenSPR, SUPR-DSF protein stability, and SX stopped-flow kinetics.
Mastering Binding Kinetics Assays
Discover how to efficiently characterize biomolecular interactions with our comprehensive eBook. Learn how the Alto™ digital SPR system simplifies interaction analysis by integrating digital microfluidics…
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using a Protein A capture reagent
Nicoya’s Protein A Capture Kit allows users to capture antibodies or Fc-tagged proteins directionally, offering an optimal orientation for analyte binding. This method also enables…
Epitope Binning
Discover how the Alto™ Digital SPR system can advance your antibody discovery workflows with the Epitope Binning application. Learn how Alto simplifies experiment design and…
Analysis of biotin-tagged proteins on Alto digital SPR using a streptavidin functionalized sensor
Nicoya’s Streptavidin Kit allows users to irreversibly capture biotinylated ligands directionally, offering anoptimal orientation for analyte binding. This method also enables users to capture ligands…
Analysis of HIS-tagged ligands on Alto digital SPR using an anti-HIS capture sensor
Nicoya’s Anti-HIS Capture Kit gives users the ability to capture histidine-tagged ligands directionally, offering an optimal orientation for analyte binding. This method also enables users…
Label-free characterization of challenging transmembrane proteins using Alto™ digital SPR
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Dr. Anil Kumar Head of CMC in Europe ACROBiosystems Overview Transmembrane proteins (TPs) serve as crucial…
Accelerating insights into changes in binding affinity of biomolecular charge variants using a simple icIEF-SPR workflow
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Chirs Heger Director of Application Science BioTechne Overview Charge heterogeneity in monoclonal antibodies can negatively impact…
Binding Kinetics of the GLP-1R Agonist Semaglutide: Practical Methods for Studying Peptide Therapeutics with SPR
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly expanding class of therapeutics for the treatment of various metabolic diseases. Characterization of their binding kinetics is…
Measuring Aggregation Propensity of a Protein using SUPR-CM
Overview
Comparing pH and Buffer Solutions for Stabilising a Monoclonal Antibody using the SUPR-CM High-Performance Plate Reader
Overview Currently, thermal approaches like differential scanning fluorimetry (DSF) and differential scanning calorimetry (DSC) are often preferred despite drawbacks like non-equilibrium measurements and thermal alteration…
Quantification of Monoclonal Antibody Stability Change After Forced Degradation Studies
Overview Forced degradation studies are routinely employed during the development of new biologics. Along with providing evidence for the mechanisms by which a mAb can…
Characterization and Quantitation of AAVs on Alto Digital SPR using AAVX & AAV9 capture surfaces
Nicoya’s AAVX & AAV9 Capture Kits use AAV-specific VHH molecules to capture AAVs on the sensor surface. This capture strategy offers an optimal orientation for…
A Simple Guide to Surface Plasmon Resonance
Are you considering going label-free for your interaction work? We’ve worked with many researchers over the years to help them succeed with SPR, and we…
Bilayer-Mediated Regulation of Membrane Protein Function by Small Molecules
Presenter: Olaf Andersen Department of Physiology and BiophysicsWeill Cornell Medical College Overview In this webinar, Dr. Olaf Anderson explores the intricate relationship between lipid bilayers…
The Wonderful World of Protein Circular Dichroism
Presenter: Krishna Mallela Associate Professor of Biophysical ChemistryUniversity of Colorado Overview In this engaging webinar, Dr. Mallela delves into the applications of circular dichroism (CD)…
Multi-Dimensional Conformation Analysis using Circular Dichroism
Presenter: Russ Middaugh Professor of Pharmaceutical Chemistry University of Kansas School of Medicine Overview In this webinar, Dr. Middaugh shares his approaches to analysing macromolecules,…
