Presenter:
Olaf Andersen
Department of Physiology and Biophysics
Weill Cornell Medical College
Overview
In this webinar, Dr. Olaf Anderson explores the intricate relationship between lipid bilayers and membrane protein function, focusing on how small molecules can regulate protein activity by altering bilayer properties. Drawing from decades of research, he uncovers the role of bilayer-mediated regulation in understanding protein conformational dynamics and drug activity.
Key Insights:
• Bilayer-Mediated Regulation: Membrane proteins undergo significant conformational changes that are energetically coupled to the bilayer’s physical properties, affecting functions such as ion transport and enzymatic activity.
• Single-Mixing Stop-Flow: This technique enables real-time measurement of bilayer modifications, providing unprecedented insight into protein-bilayer interactions.
• Amphiphile Impact: Small amphiphilic molecules, including therapeutic agents, alter bilayer properties, influencing protein functionality in both specific and non-specific ways.
• Pharmacological Implications: Findings on bilayer contributions to drug effects help clarify mechanisms behind widely used therapeutics like amiodarone and general anaesthetics.
Discover how Dr. Olaf Anderson’s research on bilayer-mediated regulation of membrane protein function is paving the way for innovative therapeutic strategies!
