Presenter:
Krishna Mallela
Associate Professor of Biophysical Chemistry
University of Colorado
Overview
In this engaging webinar, Dr. Mallela delves into the applications of circular dichroism (CD) spectroscopy to investigate protein structure, stability, and interactions. From muscular dystrophy research to biopharmaceutical protein behaviour, he highlights the powerful insights CD provides in understanding complex biomolecular mechanisms.
Key Insights:
• Secondary and Tertiary Structure Analysis: Utilising far- and near-UV CD, Dr. Mallela demonstrates how to assess protein folding, stability, and aggregation.
• Case Studies in Disease and Drug Research: Examining dystrophin mutations in muscular dystrophy and antibody interactions with excipients like polysorbates.
• Binding Dynamics: CD as a tool to characterise protein-ligand interactions, supported by complementary techniques like ITC and Raman spectroscopy.
Discover how circular dichroism spectroscopy reveals the intricate behaviours of proteins and drives progress in therapeutic protein development!
