Resources
Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Characterization of Complementary Oligonucleotide Sequences using Alto
Overview Oligonucleotides hold great potential for treating diseases linked to gene expression and have recently revolutionized the vaccine industry with the remarkable success of mRNA-based…
Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of…
Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments…
Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation…
Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of…
Kinetic and Epitope Characterization of Influenza Antiviral Targets Using Alto™ Digital Surface Plasmon Resonance
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™
Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COVID-19. This includes basic research for understanding the viral…
Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemble a specific virus without its genetic material. VLPs are frequently used to…
Protein A – IgG Interaction Analysis Using Alto™
Alto™ is a high-throughput benchtop surface plasmon resonance (SPR) instrument providing detailed binding kinetics and affinity data for a wide variety of molecular interactions. Alto™…
Binding Kinetics of an Antibody Serum Sample Using OpenSPR™
A common application of the SPR technique is antibody screening, which is critical to the development of vaccines and other immunotherapies. Since this development often…
Comparison Study of Label-Free Biosensors Using Commercially Relevant Binding Systems
Overview The OpenSPR™ is a powerful instrument providing researchers with in-depth label-free binding kinetics for a variety of different molecular interactions. A side by side…
Binding Kinetics of Aptamer-Protein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a variety of different molecular interactions. One of the most common applications of…
Binding Kinetics of Glycoprotein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a variety of different molecular interactions. One of the most common applications of…
Binding Kinetics of Protein-Protein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a variety of different molecular interactions. One of the most common applications of…
Binding Kinetics of Ubiquitin to Ubiquitin Antibody Immobilized with Protein A using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a variety of different molecular interactions. One of the most common methods of…
Binding Kinetics of Therapeutic Monoclonal Antibodies to the CD16a Fc Receptor using OpenSPR
Overview CD16a (FcyRIIIA) is an Fc receptor protein found on the surface of certain immune cells. CD16a binds to the Fc region of immunoglobulin G…
Temperature Dependent Binding Kinetics of Protein-Protein Interactions Using OpenSPR
Overview OpenSPR™ is a powerful instrument providing indepth label-free binding kinetics for a variety of different molecular interactions. One common applications of surface plasmon resonance…
