Resources
Poster: Identification of Anti-Idiotype Antibodies using Digital SPR
Overview Anti-idiotypic antibodies (anti-IDs) recognize the unique variable region of another antibody called the idiotype (defined below). Anti-IDs are commonly used in bioanalytical assays to…
Rapid, automated capture screening of influenza antiviral targets using Nicoya Alto® digital surface plasmon resonance
Overview Rapid screening and kinetic characterization of medium sized libraries is commonly seen as one of the initial steps within the drug discovery process. Screening…
Regeneration of His-tagged Streptavidin on OpenSPR® NTA Sensors Sensors
Overview Capture coupling techniques are advantageous to investigate biomolecular interactions as they provide specificity for immobilization on the OpenSPR real-time, label-free biosensor platform. Streptavidin sensors…
Analysis of proteins containing Twin-Strep-Tags on Alto Digital SPR using capture immobilization strategies
Overview The Twin-Strep-Tag® technology from IBA Lifesciences utilizes Strep-Tactin®XT to capture proteins labelled with a Twin-Strep-Tag directionally. Proteintech, a leading provider of antibody reagents, has…
Accelerating influenza antibody therapeutics with Alto™ digital microfluidic-powered epitope binning and kinetics analysis
Overview Annual formulation updates for influenza vaccines and related antibody therapies are required to preserve immune recognition against different influenza subtypes. Characterizing the binding kinetics…
Label-free characterization of transmembrane proteins using Alto™ digital SPR
Overview Many human diseases are known to be associated with transmembrane proteins (TPs), making them ideal candidates for drug development. Multi-pass transmembrane proteins are not…
Characterization of Alto™ Sample Preparation Precision and Accuracy Enabled by DMF
Overview Precise and accurate liquid handling is crucial to obtaining repeatable, high-quality data with any analytical instrument. This is especially true when preparing samples for…
Epitope Characterization of Influenza Antiviral Targets Using Alto™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Poster: Characterization of Therapeutic Antibodies using Digital SPR
Overview Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors. With simultaneous detection across 16-channels, Alto provides high-throughput analysis…
Screening of Unknown Antibodies in Complex Media with Alto™ Digital SPR
Overview Screening is a common tool used to quickly test activity of a large number of chemical or biological compounds. Commonly seen as one of…
Characterization of biosimilars derived from PlantForm’s vivoXPRESS® technology with Alto™ Digital SPR
Overview Biological drugs, or biologics, have transformed patient outcomes worldwide due to their ability to treat diseases with a higher degree of precision and specificity…
Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA and…
Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Characterization of Complementary Oligonucleotide Sequences using Alto
Overview Oligonucleotides hold great potential for treating diseases linked to gene expression and have recently revolutionized the vaccine industry with the remarkable success of mRNA-based…
Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of…
Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments…
Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation…
Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of…
