Application Note
Regeneration of His-tagged Streptavidin on OpenSPR® NTA Sensors Sensors
Overview Capture coupling techniques are advantageous to investigate biomolecular interactions as they provide specificity for immobilization on the OpenSPR real-time, label-free biosensor platform. Streptavidin sensors…
Accelerating influenza antibody therapeutics with Alto™ digital microfluidic-powered epitope binning and kinetics analysis
Overview Annual formulation updates for influenza vaccines and related antibody therapies are required to preserve immune recognition against different influenza subtypes. Characterizing the binding kinetics…
Label-free characterization of transmembrane proteins using Alto™ digital SPR
Overview Many human diseases are known to be associated with transmembrane proteins (TPs), making them ideal candidates for drug development. Multi-pass transmembrane proteins are not…
Epitope Characterization of Influenza Antiviral Targets Using Alto™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Poster: Characterization of Therapeutic Antibodies using Digital SPR
Overview Alto is the world’s first SPR instrument to integrate digital microfluidics (DMF) with nanotechnology-based biosensors. With simultaneous detection across 16-channels, Alto provides high-throughput analysis…
Screening of Unknown Antibodies in Complex Media with Alto™ Digital SPR
Overview Screening is a common tool used to quickly test activity of a large number of chemical or biological compounds. Commonly seen as one of…
Characterization of biosimilars derived from PlantForm’s vivoXPRESS® technology with Alto™ Digital SPR
Overview Biological drugs, or biologics, have transformed patient outcomes worldwide due to their ability to treat diseases with a higher degree of precision and specificity…
Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA and…
Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Characterization of Complementary Oligonucleotide Sequences using Alto
Overview Oligonucleotides hold great potential for treating diseases linked to gene expression and have recently revolutionized the vaccine industry with the remarkable success of mRNA-based…
Characterization of Fc Gamma Receptors and IgG Interactions using Alto™: Comparison to BLI
Overview Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of…
Label-Free Characterization of the Interleukin-6 Receptor and Anti-IL-6R Antibody Drug Tocilizumab using Alto™
Overview Therapeutic monoclonal antibodies are one of the fastest growing classes of drugs, and interleukins and their signal pathways are a preeminent target for treatments…
Label-Free Characterization of ImmTAC® Bispecific Molecules for T-Cell Redirecting Immunotherapy using Alto™
Overview Bispecific proteins offer a promising new modality for the treatment of cancer and have subsequently gained attention in recent years as the next generation…
Characterization of Biomolecular Interactions using Alto™: Comparison to Conventional SPR
Overview Label-free analysis of biomolecular interactions is a critical tool for the development of biologics. Conventional label free analytical instruments require relatively large amounts of…
Kinetic and Epitope Characterization of Influenza Antiviral Targets Using Alto™ Digital Surface Plasmon Resonance
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™
Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COVID-19. This includes basic research for understanding the viral…
Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemble a specific virus without its genetic material. VLPs are frequently used to…
Protein A – IgG Interaction Analysis Using Alto™
Alto™ is a high-throughput benchtop surface plasmon resonance (SPR) instrument providing detailed binding kinetics and affinity data for a wide variety of molecular interactions. Alto™…
