See further with Chirascan
Confidently characterize structure, interactions, and stability across biologics and small molecules.
See your molecules more clearly than ever
Chirascan builds on the foundations of traditional circular dichroism with deeper, multi-dimensional insights and built-in analytical precision. While many spectrometers focus on basic secondary structure, Chirascan empowers you to resolve tertiary changes, thermodynamic transitions, kinetics, and higher-order structural differences with the sensitivity, automation, and statistical confidence needed for advanced biological and regulatory workflows.
Determine innovator HOS characteristics. CD analysis of tertiary structure in a highly absorbing chiral formulation buffer suggested differences in tryptophan region of Fab fragments from different innovator lots.
Sensitivity that reveals the subtle
Detect even the smallest structural shifts with advanced, low-noise optics with the most sensitive CD instrument on the market. Chirascan’s optimized optics and detectors deliver industry-leading sensitivity across UV and near-UV wavelengths, enabling detection of subtle tertiary changes and low-signal transitions that can be challenging for conventional CD spectrometers to resolve.
Automation that saves you time
Unattended runs, automated measurements, and cuvette washing let you keep experiments moving without hands-on time. Spend less time managing the instrument – and more time interpreting meaningful data.
Deep insights in every experiment
Collect CD, absorbance, fluorescence, and full-wavelength thermodynamic data in a single, integrated workflow without having to switch instruments, as is often required with traditional CD systems. With precise temperature control and integrated analysis, you get more information in less time and make faster, evidence-backed decisions.
Every stage of discovery
Chirascan VX
Essential CD Performance.
The gold-standard CD instrument for routine structural analysis. Chirascan VX delivers exceptional data quality through high-throughput optics, intuitive workflows, and precise thermal control—ideal for core research labs and foundational biophysical studies.
Chirascan V100
High Sensitivity, Broader Insight.
Chirascan V100 delivers a performance upgrade with enhanced sensitivity, faster acquisition, and an extended wavelength range. Chirascan V100 excels with low-concentration samples, complex buffers, and advanced thermal or kinetic studies, offering more detail where it matters most.
Chirascan Q100
Automated Precision for QA/QC.
Built for regulated environments, Chirascan Q100 adds full automation for reproducible, unattended, HOS analysis. Streamlines biosimilar assessment, comparability studies, and QC workflows with data consistency that supports global regulatory submissions.
Built to fit your science
Adapt Chirascan to any workflow with modular accessories and flexible measurement modes. Extend beyond standard CD to capture orthogonal insights and tailor the system to your exact research needs.
Unlock structural insights with precision
Chirascan gives you direct visibility into the structure, stability, and dynamics of proteins, peptides, nucleic acids, and complex biomolecules. By combining CD with absorbance, fluorescence, and advanced temperature control, it reveals higher-order structural changes that drive biological function — enabling faster, more confident decision-making.
Higher-Order Structure (HOS) Characterization
Monitor subtle tertiary and quaternary structural changes using highly sensitive near-UV CD. Chirascan detects shifts in aromatic environments, disulfide bond geometry, and conformational microheterogeneity.
Chirascan’s multiwavelength calibration corrects instrument response across the full spectral range, improving quantitative accuracy and ensuring reliable, reproducible CD measurements
Precision you can trust
Circular Dichroism provides reliable, label-free insight into molecular structure, interactions, and stability. Chirascan builds on this proven foundation with advanced optics, high-sensitivity detection, and automated workflows that ensure reproducible, publication-quality data for confident scientific and regulatory decisions
Resources
Chirascan Platform Brochure
Learn more about the Chirascan platform
Far-UV CD Analysis During Biotherapeutic Development: A Method Capability Study
Overview In this study carried out by Novartis, far- UV CD spectroscopy was qualified for the early development of a monoclonal antibody therapeutic. The high…
Shining Light on Non-Chemical Steps in Protein Catalysis
Overview Stopped-flow experiments using Applied Photophysics SX20 and Chirascan V100 SF.3 systems allow monitoring of different spectral properties including fluorescence, absorbance, and even far-and near-UV…
See Structure Clearly. Make Decisions Confidently
Unlock deeper insights into protein stability, folding, and higher-order structure.
