See further with Chirascan
Confidently characterize structure, interactions, and stability across biologics and small molecules.
See your molecules more clearly than ever
Chirascan builds on the foundations of traditional circular dichroism with deeper, multi-dimensional insights and built-in analytical precision. While many spectrometers focus on basic secondary structure, Chirascan empowers you to resolve tertiary changes, thermodynamic transitions, kinetics, and higher-order structural differences with the sensitivity, automation, and statistical confidence needed for advanced biological and regulatory workflows.
Determine innovator HOS characteristics. CD analysis of tertiary structure in a highly absorbing chiral formulation buffer suggested differences in tryptophan region of Fab fragments from different innovator lots.
Sensitivity that reveals the subtle
Detect even the smallest structural shifts with advanced, low-noise optics with the most sensitive CD instrument on the market. Chirascan’s optimized optics and detectors deliver industry-leading sensitivity across UV and near-UV wavelengths, enabling detection of subtle tertiary changes and low-signal transitions that can be challenging for conventional CD spectrometers to resolve.
Automation that saves you time
Unattended runs, automated measurements, and cuvette washing let you keep experiments moving without hands-on time. Spend less time managing the instrument – and more time interpreting meaningful data.
Deep insights in every experiment
Collect CD, absorbance, fluorescence, and full-wavelength thermodynamic data in a single, integrated workflow without having to switch instruments, as is often required with traditional CD systems. With precise temperature control and integrated analysis, you get more information in less time and make faster, evidence-backed decisions.
Every stage of discovery
Chirascan VX
Essential CD Performance.
The gold-standard CD instrument for routine structural analysis. Chirascan VX delivers exceptional data quality through high-throughput optics, intuitive workflows, and precise thermal control—ideal for core research labs and foundational biophysical studies.
Chirascan V100
High Sensitivity, Broader Insight.
Chirascan V100 delivers a performance upgrade with enhanced sensitivity, faster acquisition, and an extended wavelength range. Chirascan V100 excels with low-concentration samples, complex buffers, and advanced thermal or kinetic studies, offering more detail where it matters most.
Chirascan Q100
Automated Precision for QA/QC.
Built for regulated environments, Chirascan Q100 adds full automation for reproducible, unattended, HOS analysis. Streamlines biosimilar assessment, comparability studies, and QC workflows with data consistency that supports global regulatory submissions.
Built to fit your science
Adapt Chirascan to any workflow with modular accessories and flexible measurement modes. Extend beyond standard CD to capture orthogonal insights and tailor the system to your exact research needs.
Unlock structural insights with precision
Chirascan gives you direct visibility into the structure, stability, and dynamics of proteins, peptides, nucleic acids, and complex biomolecules. By combining CD with absorbance, fluorescence, and advanced temperature control, it reveals higher-order structural changes that drive biological function — enabling faster, more confident decision-making.
Higher-Order Structure (HOS) Characterization
Monitor subtle tertiary and quaternary structural changes using highly sensitive near-UV CD. Chirascan detects shifts in aromatic environments, disulfide bond geometry, and conformational microheterogeneity.
Measure Protein Stability
Track the loss of secondary or tertiary structure as temperature increases to uncover thermal resilience. Determine key stability metrics like Melting temperature (Tm), Enthalpy of unfolding (ΔHvH), Onset temperature (Tonset), and Thermal reversibility
Maximize Data Efficiency
With industry-leading sensitivity, get high resolution thermodynamic and structural insights in a single experiment. Get a complete picture of protein structure for quality control with minimal sample concentration.
Chirascan’s multiwavelength calibration corrects instrument response across the full spectral range, improving quantitative accuracy and ensuring reliable, reproducible CD measurements
Precision you can trust
Circular Dichroism provides reliable, label-free insight into molecular structure, interactions, and stability. Chirascan builds on this proven foundation with advanced optics, high-sensitivity detection, and automated workflows that ensure reproducible, publication-quality data for confident scientific and regulatory decisions
Resources
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using mouse Fc-specific capture reagents
Overview Mouse Fc-specific capture reagents can be used to capture mouse antibodies or Fc-tagged proteins directionally. These capture reagents offer an optimal orientation for analyte…
Nicoya Alto CBX Cartridge Sensor Performance
With Alto, Nicoya’s Digital surface plasmon resonance™ (SPR) platform, the entirety of the fluidic control and sensing is done on single-use disposable cartridges. High accuracy…
Uncovering New Tools to Analyze Cytokine–Receptor Interactions: How Conigen Bioscience Used Nicoya’s Alto™ Digital SPR to Characterize Novel Dimeric Receptors
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Alyssa Ball, PhD Professor, Assay Development Scientist Conigen Bioscience Overview Understanding cytokine-receptor interactions is critical for…
See Structure Clearly. Make Decisions Confidently
Unlock deeper insights into protein stability, folding, and higher-order structure.
