The reproducibility of several sensor metrics was assessed across four streptavidin (STV) cartridges from different lots. From this study, sensitivity, immobilization, and analyte response were all found to vary by <2% within and <5% across cartridges. A kinetics test was also performed, testing a single interaction across all sensors, showing variability of <6% for immobilization and Rmax and <20% for ka and kd across 72 replicates.
The development of biosimilar monoclonal antibodies requires rigorous demonstration of structural and functional equivalence to the reference product under a regulatory “totality of evidence” framework.…
Plate-based intrinsic DSF delivers both melting temperature (Tm) and non-reversibility onset (Tnr)—providing faster, more affordable stability analysis directly in your standard microplate workflow.
The development of biotherapeutics requires rigorous evaluation of both conformational and colloidal stability. In this application note, we introduce a new temperature cycling capability for…
