Discovery & Optimization
Explore molecular interactions, characterize emerging candidates, and deepen your scientific understanding with fast, sensitive label-free tools that deliver dependable, publication-quality results.
Accelerate early discovery with real-time, label-free insights that go far beyond affinity.
Nicoya’s digital SPR platforms, paired with rapid protein stability screening using SUPR-DSF, combine ultra-low sample consumption, maintenance-free cartridge workflows, and high-throughput capabilities to help you rapidly identify hits, rank affinities, and assess developability long before investing in costly downstream assays. Designed for agile teams across academia, biotech, CROs, and pharma, our systems make it easy to generate reproducible kinetics and stability data at scale, enabling faster iteration, reduced risk, and smarter decision-making from the very start of discovery.
Featured Products
Alto
High-throughput, automation-ready digital SPR that turns complex kinetics into simple answers.
Alto delivers the gold-standard kinetic resolution with the ease and automation that modern discovery workflows demand. With 16 channels, integrated DMF, and hands-free assay setup, Alto enables parallel screening, affinity ranking and complete kinetic characterization at scale, ideal for CROs, pharma teams, and optimization groups needing both speed and depth.
Revo
4- or 8- channel digital SPR for gold-standard data while balancing throughput, flexibility and cost.
Built for innovators in small labs and academic research, Revo makes high-quality kinetics truly accessible. With cartridge-based workflows, ultra-low sample consumption, and simple experiment setup, Revo empowers teams to screen candidates, explore binding behavior, and generate reproducible interaction data—without the maintenance burden of conventional SPR.
OpenSPR
An entry-level, robust SPR for agile, exploratory science.
A cost-effective, 2-channel benchtop SPR system designed for scientists beginning structure–function exploration. OpenSPR delivers reliable affinity and kinetics data using minimal sample, helping academic labs and first-time SPR users validate hits and characterize interactions with a beginner-friendly manual system.
SUPR-DSF
Plate-based intrinsic DSF for thermal shift screening
Thermal shift screening provides early insight into binding interactions, candidate ranking, and protein stability within a single, streamlined workflow. Experiments performed in a standard 384-well plate format integrate easily into modern laboratory environments while supporting flexible experimental design. As study demands grow, compatibility with automation allows workflows to scale efficiently, enabling consistent data generation and confident decision-making without adding complexity.
Resources
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using mouse Fc-specific capture reagents
Overview Mouse Fc-specific capture reagents can be used to capture mouse antibodies or Fc-tagged proteins directionally. These capture reagents offer an optimal orientation for analyte…
Nicoya Alto CBX Cartridge Sensor Performance
With Alto, Nicoya’s Digital surface plasmon resonance™ (SPR) platform, the entirety of the fluidic control and sensing is done on single-use disposable cartridges. High accuracy…
Uncovering New Tools to Analyze Cytokine–Receptor Interactions: How Conigen Bioscience Used Nicoya’s Alto™ Digital SPR to Characterize Novel Dimeric Receptors
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Alyssa Ball, PhD Professor, Assay Development Scientist Conigen Bioscience Overview Understanding cytokine-receptor interactions is critical for…
Uncover the interactions that matter
Talk with our team to learn how to make your science simpler, clearer, and more scalable.
