The Revolution is now.
Meet Revo, the four- or eight-channel digital SPR benchtop system that’s high impact—not high cost.
Revo fills critical gaps in SPR by combining digital microfluidics with nanotechnology-based biosensors in a compact, affordable system. Its disposable cartridge supports the same throughput as a 96 well plate (four-channel), without fluidics maintenance and with crude sample compatibility. With low sample requirements, full automation, and consistent, publication-quality data, Revo makes gold-standard SPR accessible, scalable, and cost-effective for any lab.
Digital SPR, simplified
Revo brings the precision of traditional SPR into an accessible, intuitive benchtop platform. By merging digital microfluidics with nanotechnology-based biosensors, scientists gain direct access to high-quality, reproducible kinetic data, without the training, maintenance, or complexity associated with legacy SPR systems.
Low sample, high impact
With just 2 μL of sample and up to 18 interactions per four-channel disposable cartridge or 36 interactions per eight-channel disposable cartridge, Revo dramatically reduces sample consumption and hands-on time. Automated serial dilutions and buffer movements minimize workflow burden, enabling faster iteration and more cost-effective experiments across research teams.
Maintenance-free reliability
Revo’s disposable cartridges eliminate fluidics maintenance and support interactions even from crude samples. This ensures consistent performance, minimizes downtime, and empowers users to generate publication-quality data again and again, without specialized skills or costly service contracts.
Supported Applications
Binding Kinetics & Affinity
Measure real-time association and dissociation rates to understand how molecules interact, how strongly, and how fast. Revo provides high-quality SPR kinetic data ideal for biologics engineering, peptide discovery, antibody optimization, and early mechanism validation.
Hit Screening & Ranking
Quickly identify the most promising candidates with low sample consumption and automated workflows. Revo’s cartridge-based system allows screening of up to 36 interactions per run, even when working with crude or precious samples.
Quantitation & Titering
Quickly measure the concentration of your proteins in crude expression media. Automated sample handling, and integrated concentration determination improve accuracy while minimizing hands-on time. Perfect for QC, translational teams, and academic labs.
Custom Protocols
Powered by digital microfluidics, Revo supports flexible assay design, enabling unique workflows, and tailored experimental configurations that are not possible on traditional systems.
Digital microfluidics meets SPR
Revo integrates digital microfluidics with advanced nanotechnology-based biosensors inside a sealed, disposable cartridge. This architecture eliminates fluidics maintenance, reduces sample use, supports crude samples, and ensures consistent assay performance, bringing gold-standard SPR data to any benchtop.
Product Specifications
| Category: | Specification: |
|---|---|
| Throughput | 4 channels; up to 18 interactions / 90 curves per assay 8 channels; up to 36 interactions / 180 curves per assay |
| Sample Volume | Minimum 2 μL |
| Cartridge Types | Multiple surface chemistries; crude-compatible |
| Technology | Digital microfluidics + LSPR biosensors |
| Automation | Automation compatible with software API; Automated sample/buffer movement, serial dilutions |
| Maintenance | None (disposable cartridge) |
| Footprint | Benchtop system – 1.5H x 1W x 1.5D (ft) |
| Affinity Range | pM – mM |
| Applications | Kinetics, affinity, screening, quantitation, custom protocols |
Resources
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using mouse Fc-specific capture reagents
Overview Mouse Fc-specific capture reagents can be used to capture mouse antibodies or Fc-tagged proteins directionally. These capture reagents offer an optimal orientation for analyte…
Nicoya Alto CBX Cartridge Sensor Performance
With Alto, Nicoya’s Digital surface plasmon resonance™ (SPR) platform, the entirety of the fluidic control and sensing is done on single-use disposable cartridges. High accuracy…
Uncovering New Tools to Analyze Cytokine–Receptor Interactions: How Conigen Bioscience Used Nicoya’s Alto™ Digital SPR to Characterize Novel Dimeric Receptors
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Alyssa Ball, PhD Professor, Assay Development Scientist Conigen Bioscience Overview Understanding cytokine-receptor interactions is critical for…
Are you ready to challenge convention?
Talk with our team to learn how to make your science simpler, clearer, and more scalable.
