Overview
Forced degradation studies are routinely employed during the development of new biologics. Along with providing evidence for the mechanisms by which a mAb can degrade, the change in
stability mimics the observations when comparing different antibody constructs.
The change in stability of an IgG1 mAb was measured via chemical denaturation before and after deamidation, glycation, and oxidation studies. Samples prepared in 384-well microplates were measured with the SUPR-CM fluorescence plate reader.
