Xu, X.; Piao, H. N.; Aosai, F.; Zeng, X. Y.; Cheng, J. H.; Cui, Y. X.; Li, J.; Ma, J.; Piao, H. R.; Jin, X.; Piao, L. X., Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways. Br J Pharmacol 2020, 177 (22), 5224-5245.
Interaction Type: Peptide-small molecule
Abstract: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant-like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microglia via high-mobility group box 1 (HMGB1)/TLR4/NF-κB and TNF-α/TNFR1/NF-κB signaling pathways, leading to depression. In this study, we have investigated the antidepressant mechanism of arctigenin by conducting in vitro and in vivo studies.