Mechanism of Action & Characterization
Reveal how molecules bind, fold, react, and evolve by integrating orthogonal biophysical techniques that clarify interactions, structural shifts, and mechanisms of action.
Bring mechanism and molecular behavior into sharp detail
Nicoya’s mechanism-focused portfolio integrates digital SPR, high-sensitivity circular dichroism, and ultra-fast kinetics to illuminate binding mechanisms, structural transitions, conformational shifts, allostery, and rapid reaction intermediates that traditional tools often miss. Whether you’re mapping epitopes, distinguishing competitive interactions, probing higher-order structure, or quantifying millisecond kinetics, our platforms deliver deep, publication-grade mechanistic insight with minimal setup and hands-on time.
By unifying affinity, structure, dynamics, and stability into a cohesive workflow, Nicoya enables researchers across industry and academia to make confident decisions rooted in true molecular understanding.
Featured Products
Alto
High-throughput, automation-ready digital SPR that turns complex kinetics into simple answers.
Ideal for binding mechanisms, epitope binning, competitive assays, and detailed kinetic analysis.
SX20
Study millisecond reactions in solution – reliably capture reaction mechanisms, rates and intermediates.
Dual detection, automated dead-time correction, and unmatched sensitivity make SX20 the most cited stopped-flow system in the world.
Chirascan
The industry’s most sensitive CD system for detecting subtle secondary and tertiary structural changes – even with low signals.
Characterize protein structure, monitor conformational changes, and study thermal unfolding with confidence. Chirascan supports detailed functional insight, comparability studies, and stability assessment with high-precision performance.
Resources
Analysis of antibody-antigen binding kinetics on Alto Digital SPR using mouse Fc-specific capture reagents
Overview Mouse Fc-specific capture reagents can be used to capture mouse antibodies or Fc-tagged proteins directionally. These capture reagents offer an optimal orientation for analyte…
Nicoya Alto CBX Cartridge Sensor Performance
With Alto, Nicoya’s Digital surface plasmon resonance™ (SPR) platform, the entirety of the fluidic control and sensing is done on single-use disposable cartridges. High accuracy…
Uncovering New Tools to Analyze Cytokine–Receptor Interactions: How Conigen Bioscience Used Nicoya’s Alto™ Digital SPR to Characterize Novel Dimeric Receptors
Presenters: Michael Piazza, PhD AVP, Applications Development Nicoya Lifesciences Alyssa Ball, PhD Professor, Assay Development Scientist Conigen Bioscience Overview Understanding cytokine-receptor interactions is critical for…
Understand how your molecules work
Reveal how your molecules bind, fold, react, and change with the industry’s most comprehensive biophysical toolkit.
