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Exploring Molecular Interactions with OpenSPR: A Perspective from the Johal Lab
We recently talked to Professor Malkiat S. Johal, a Professor of Physical Chemistry at Pomona Colleg...
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Customer Testimonials – OpenSPR
“OpenSPR offers the perfect combination of performance and affordability, which will accelerate ou...
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OpenSPR
OpenSPR System OpenSPR Software OpenSPR Sensors Get the data you’ve been missing with uncompro...
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Webinar On-Demand: Streamlining characterization of biomolecular binding kinetics with alto™ and openspr®
Webinar On-Demand Streamlining Characterization of Biomolecular Binding Kinetics with Alto™ and Op...
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Researcher Spotlight: Uncovering the molecular mechanisms of muscle function using OpenSPR
Learn about how OpenSPR user Sabrina Apel employs Nicoya’s SPR technology to study protein-pro...
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From bench to publication: How OpenSPR® has galvanized label-free studies of diseases across the globe
Explore how OpenSPR is advancing disease research in over 200 peer-reviewed publications Affordabili...
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Regeneration of His-tagged Streptavidin on OpenSPR® NTA Sensors Sensors
Overview Capture coupling techniques are advantageous to investigate biomolecular interactions as th...
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Streamlining biomolecular binding characterization with Alto™ and OpenSPR® – On Demand
Webinars Streamlining characterization of biomolecular binding kinetics with Alto™ and OpenSPR® D...
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Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022
Hanson, E.K.; Whelan, R.J. Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A R...
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Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as ...
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Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloak...
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OpenSPR Binding Data Reveals a Potential Mechanism for the Treatment of Depression
Introduction Depression is becoming more and more common worldwide, with approximately 1 in 30 peopl...
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OpenSPR Binding Data Reveals a Potential Mechanism for the Treatment of Depression
Introduction Depression is becoming more and more common worldwide, with approximately 1 in 30 peopl...
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Application Note: Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain using OpenSPR-XT™
High-affinity SARS-CoV-2 antibody characterized using Surface Plasmon Resonance (SPR). Finding a Sol...
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Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™
Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COV...
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App Note: Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Virus-like particles (VLPs) are complex molecules composed of multiple protein subunits that resembl...
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Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemb...
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App Note: Binding Kinetics of an Antibody Serum Sample Using OpenSPR™
You asked. We answered. Our team at Nicoya speaks with hundreds of researchers every week. We regula...
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Binding Kinetics of an Antibody Serum Sample Using OpenSPR™
A common application of the SPR technique is antibody screening, which is critical to the developmen...
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New Publication – OpenSPR™ Binding Data Reveals Novel Mechanisms of Alzheimer’s Disease
Over 50 million people worldwide have been diagnosed with Alzheimer’s Disease (AD) or another form...
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Publication – OpenSPR Binding Data Reveals a Novel Approach to Treat Chronic Itch
Chronic itch associated diseases such as eczema and psoriasis will affect over 20% of human beings d...
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Cut Your Lab Instrument Downtime to 0 Using OpenSPR™
Having the right tools is essential for any profession. A chef cannot cook without knives, and a car...
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App Note: Binding Kinetics of Protein-Protein Interactions using OpenSPR™
Are protein binding kinetics important for your research? Benchtop SPR is a user-friendly tool that ...
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New Publication – OpenSPR Binding Data Establishes A Novel In Vivo Imaging Technique
For decades, Green Fluorescent Protein (GFP) has been used as a novel cell and molecular biology too...
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New Publication – OpenSPR Binding Data Enhances Nanotherapeutic Construction with Molecular Affinity Strategy
In order for drugs to fight diseases, an efficient delivery method must be found. This necessitates ...
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OpenSPR Binding Data Uncovers Antipsychotic Drug Mechanisms
Over the last number of years, there’s been an increasing amount of attention on combating mental ...
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Binding Kinetics of Aptamer-Protein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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Binding Kinetics of Glycoprotein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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Binding Kinetics of Protein-Protein Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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Binding Kinetics of Ubiquitin to Ubiquitin Antibody Immobilized with Protein A using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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Binding Kinetics of Therapeutic Monoclonal Antibodies to the CD16a Fc Receptor using OpenSPR
Overview CD16a (FcyRIIIA) is an Fc receptor protein found on the surface of certain immune cells. CD...
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Temperature Dependent Binding Kinetics of Protein-Protein Interactions Using OpenSPR
Overview OpenSPR™ is a powerful instrument providing indepth label-free binding kinetics for a var...
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Binding Kinetics of Protein-Small Molecule Interactions using OpenSPR
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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OpenSPR 2-Channel Instrument for Protein Interaction Analysis
Overview OpenSPR™ is a powerful instrument providing in-depth label-free binding kinetics for a va...
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OpenSPR-XT Demo Request
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OpenSPR Quote Request
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OpenSPR Binding Data Uncovers Virulence Mechanism of Streptococcus pyogenes
Virulence factors are tools employed by pathogenic organisms to utilize, evade, colonize, suppress o...
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OpenSPR for Education
Benefits of Teaching Labs For Students: Hands-on experience Increase employability For Teachers: Low...
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Advancing Neuromuscular Disease Research with OpenSPR Binding Data
The human nervous system is a complex collection of over 100 billion nerve cells that regulate count...
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OpenSPR Instruments
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OpenSPR Binding Data Advances Delivery Method of Photodynamic Cancer Therapeutics
Dr. Xiaofeng Liu recently published a paper using binding data generated from OpenSPR to reveal an e...
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OpenSPR-XT Binding Data Opens New Doors for Targeting of RNA Binding Proteins for Glioblastoma Therapeutics
Dr. Luis Penalva recently published a paper using binding data generated from the OpenSPR-XT’s aut...
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Discovery of a Gene Regulation Network in P. aeruginosa Biofilm Production using OpenSPR Binding Data
Dr. Tung T. Hoang recently published a paper using binding data generated from OpenSPR to quantify t...
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The OpenSPR Centre of Excellence – Building a Community of Innovative Researchers in India & Beyond
Dr. Ramaswamy (Dr. Rams) is a leading scientist in India with over 100 publications to date. In coll...
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OpenSPR Binding Data Advances Peptide Screening Methods
Dr. Leonard Luyt recently published a paper using binding data generated from the OpenSPR to quantif...
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OpenSPR Binding Data Advances Targeting Potential of Anti-Cancer Therapeutics
Dr. Huile Gao recently published a paper that unveils how protein corona formation may significantly...
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OpenSPR Antibody Binding Data Challenges Traditional Hepatitis B Vaccination Strategies
Dr. Yu-Ching Lee recently published a paper challenging traditional hepatitis B vaccination (HBV) st...
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OpenSPR Phospholipid Binding Data Advances Cardiac Health Research
Dr. Zeczycki, a researcher at East Carolina University, uses OpenSPR’s surface plasmon resonance t...
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OpenSPR Binding Data Helps Advance Cervical Cancer Therapies
Dr. Zhang recently published a paper demonstrating the disruption potential of small molecules synth...
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Determination of Protein Concentrations using OpenSPR
Looking for quick, easy and affordable protein concentration analysis? Benchtop SPR can help. In our...
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OpenSPR Binding Data Helps Advance Biotherapeutic Drug Discovery
Dr. Brown, a researcher at Lehigh University, uses OpenSPR’s surface plasmon resonance technology ...
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OpenSPR Binding Data Helps Advance Ageing & Cancer Research
Dr. Roth, a researcher at the Medical University of South Carolina, uses OpenSPR’s surface plasmon...
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OpenSPR Binding Data Helps Advance Cancer Drug Discovery
Dr. Lu, a researcher at Sichuan University, uses OpenSPR’s surface plasmon resonance technology to...
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How OpenSPR helped Dr. Espie Publish his Groundbreaking Research
Do you want to publish your research sooner? Dr. George Espie from the University of Toronto reveals...
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App Note: Binding Kinetics of Protein-Protein Interactions using OpenSPR™
Are protein binding kinetics important for your research? Benchtop SPR is a user-friendly tool that ...
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Hot New App Note: Temperature Dependent Binding Kinetics of Protein-Protein Interactions Using OpenSPR™
Is temperature dependence important for your binding interactions? In our hot new application note ...
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OpenSPR-XT
Compatible Molecules: Supported Assays: Technical Specifications Performance Association Rate (kon) ...
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OpenSPR Sensors
Surface Chemistries Sensor Chip: Coated for the immobilization of: Carboxyl any amine group using ED...
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OpenSPR Software
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Corporate Update: Nicoya acquires Applied Photophysics to accelerate biologics drug discovery and development
Today marks a significant milestone for Nicoya as we announce our acquisition of Applied Photophysic...
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Products
OpenSPR OpenSPR-XT OpenSPR Sensors OpenSPR Analysis Software Alto Alto Automation Suite Alto GxP Sui...
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Customer Testimonials
OpenSPR Testimonials READ MORE Alto Testimonials READ MORE...
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Nicoya’s Homepage
Run label-free analysis 24/7 Meet Alto, the world’s first fully automatable SPR system LEARN M...
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Webinar on demand: Optimizing nucleic acid and antibody binding assays with SPR: Proven approaches and practical insights
Webinar On Demand Optimizing nucleic acid and antibody binding assays with SPR: Proven approaches an...
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Optimize Nucleic Acid and Antibody Binding Assays Webinar – On Demand
Webinars Optimizing nucleic acid and antibody binding assays with SPR: Proven approaches and practic...
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DART.2: Duke scientists make innovation in precision drug delivery
Researchers at Duke University led by Dr. Michael Tadross made a significant contribution to the fie...
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Introduction to Digital SPR and its use in DART – On Demand
Webinars Introduction to Digital SPR and its use in assessing the binding kinetics of DART Details D...
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Hello Boston, Meet Nicoya.
We are super excited to introduce our new lab in Boston! Meet the dynamic team behind the launch and...
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Helping scientists succeed in the Bay Area: Meet the team behind our new San Francisco lab
We’re excited to announce the opening of our brand-new lab facility in San Francisco! Meet the tea...
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From droplets to kinetics: Exploring the fundamentals of digital microfluidics and SPR
Alto™ leverages digital microfluidics technology to streamline SPR workflows by automating and min...
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Become an SPR expert with our 10 tips for success
From assay design to optimization, our top 10 tips will guide you to success! After months of resear...
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Keeping up with viral evolution: How SPR streamlines prevention and treatment of influenza
Our next generation SPR platforms provide high-quality data and streamline research workflows to giv...
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SPR vs ELISA: Comparing techniques for biomolecular detection
Binding analysis with surface plasmon resonance (SPR) provides both affinity and kinetics data, givi...
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2022 wrapped: Celebrating 10 years at Nicoya
We took a moment to look back on the key events that shaped this milestone year. By Ryan Denomme, Co...
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What’s in store for 2022? Announcing our $20M Series A Extension
Equipping biologics researchers with disruptive tools in the era of proteomics Ryan Denomme, Co-foun...
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Webinars
Webinars Publications Blog Application Notes eBooks & Tech Notes Webinars What is SPR? Alto Lab ...
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Cryo-EM and SPR: Complementary technologies providing structural and functional insights toward advancing coronavirus research
How did two cutting-edge technologies ultimately enable researchers to develop COVID-19 vaccines at ...
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Surface Plasmon Resonance Sensors: A Comprehensive Guide for Scientists
Getting ready to plan for your surface plasmon resonance (SPR) experiments? Great! So, you probably ...
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Homepage
We empower scientists with accessible SPR instrumentation Alto Alto is the world’s first SPR inst...
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Ways to Get Research Funding During COVID-19
In support of COVID-19, North American government agencies are funding research grant opportunities....
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Complimentary SPR Support Now Available to All Researchers during COVID-19
UPDATE: Discontinuation of Complimentary SPR Support It had been our pleasure to offer complime...
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Technical Guide: Expert Tips on Publishing Your SPR Data
Trying to get your research manuscript accepted faster? Publishing your work is an incredibly ...
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How Preconcentration can save your Protein Samples in SPR Experiments
Your protein is precious. The more sample that you can save, the less time you need to spend on expr...
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Nicoya Raises $10 Million in Series A Funding to Make Drug Discovery Digital
KITCHENER, ON – January 14, 2020 – Nicoya, a leading provider of advanced analytical instruments...
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Comparison: Surface Plasmon Resonance (SPR) vs. Surface Plasmon Resonance Imaging (SPRi)
In competitive areas of biomedical research, such as drug discovery and vaccine development, choosin...
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Case Study: The Importance of Binding Kinetics in Drug Discovery
Drug discovery is a critical and complex area of research. Rigorous testing, crucial safety consider...
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Technical Guide: Epitope Mapping Techniques
Whether you’re developing a novel vaccine or designing antibody therapeutics, chances are you have...
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Technical Guide: Conducting In Vitro Assays with Transmembrane Proteins
Transmembrane proteins account for approximately 50% of the total mass in a lipid bilayer and serve ...
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How to Write a Successful Grant Proposal
You’re passionate about your research. Your work is crucial for scientific discovery and deserves ...
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5 Tips on Getting Published in a High-Impact Journal
How do you define success as an academic researcher? We’ve spoken with thousands of academic resea...
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4 Types of Binding Assays You Can Do With SPR
Whether you’re designing novel antibodies for your groundbreaking vaccine work or you’re breakin...
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Improving SPR Data Quality: Controls, Design and Optimization
Accuracy, precision and reproducibility are the three most important principles in scientific resear...
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Technical Guide: Comparing SPR and QCM
Selecting the right lab equipment for your projects is always a challenge. With the number of techni...
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Biolayer Interferometry vs Surface Plasmon Resonance Comparison
Deciding which methods your lab should invest in can be challenging. Cost, experiment time and repro...
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How to Confront the Antibody Reproducibility Crisis using SPR
Have you ever ordered antibodies from an antibody supplier? Have you ever had a problem with antibod...
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The ABC’s of Competitive Binding Assays with SPR
In the arena of drug discovery, there are a number of tools available for researcher’s to characte...
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Technical Guide: Binding Assays with Flow Cytometry and SPR
Flow cytometers are excellent tools for the modern cell biologist and immunologist. They can provide...
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Preparing for Publication: Identification and Characterization
In our previous blog post, we explored some of the most commonly used structures for expression and ...
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Software updates
Download the latest release of Nicoya Lifesciences OpenSPR software OpenSPR Software 4.5.8846.19906 ...
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Preparing for Characterization: Expression and Purification
When proposing a research project, there’s a number of project steps that require advanced plannin...
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Terms of Sale
General Terms and Conditions of Sale These General Terms and Conditions of Sale (“General Terms”...
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Comparison Study of Label-Free Biosensors Using Commercially Relevant Binding Systems
Summary Binding kinetics of biotinylated CD16a and IgG were characterized by comparing OpenSPR™ wi...
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Our Mission: Improving Human Life by Helping Scientists Succeed
How is your research changing the world? Over the past 5 years, we’ve had the opportunity to help ...
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Comparison Study of Label-Free Biosensors Using Commercially Relevant Binding Systems
Overview The OpenSPR™ is a powerful instrument providing researchers with in-depth label-free bind...
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Software updates
Download the latest release of Nicoya Lifesciences OpenSPR software OpenSPR Software 3.11.6949.28944...
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News
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LSPR vs. SPR
Localized surface plasmon resonance is generated by metal nanoparticles, typically gold or silver, a...
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Nanoparticles
Outcomes: Biosensor development & optimization Nanomaterials synthesis evaluation and quality co...
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Small Molecules
Outcomes: Determine kon and koff (kinetics) and KD (affinity) values Yes/No Bind...
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Nucleic Acids/Aptamers
Outcomes: Determine kon and koff (kinetics) and KD (affinity) values Quantify le...
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Lipids
Outcomes: Determine kon and koff (kinetics) and KD (affinity) value Yes/No Bindi...
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Carbohydrates
Outcomes: Determine kon and koff (kinetics) and KD (affinity) values Quantify le...
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Proteins
Outcomes: Determine kon and koff (kinetics) and KD (affinity) values Quantify le...
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Pros & Cons of Fluorescence-Based Binding Assays
As the availability of affordable technology increases, reviewers are constantly requesting binding ...
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How SPR Fits in Your Interaction Research Workflow
Trends in Publications How do you measure success as an academic researcher? Although there are many...
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Prime Minister Justin Trudeau Meets with Nicoya CEO Ryan Denomme
Nicoya demonstrates their innovative sensor technology to Canada’s Prime Minister Justin Trudeau W...
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New Automated SPR Levels the Playing Field in Protein Science
OpenSPR-XT will accelerate discoveries in protein science by offering affordable & fully automat...
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What is SPR?
Publications Blog Application Notes eBooks & Tech Notes Webinars What is SPR? Alto Lab Catalyst ...
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Improve Your SPR Data Quality by 4X with New High Sensitivity Sensors
Combined with 2-Channel benchtop SPR technology, High Sensitivity Sensors enable a 4x sensitivity in...
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Binding Kinetics of Protein A and IgG using 2-Channel Benchtop SPR
The 2-Channel OpenSPR is ideal for generating high quality and highly reproducible binding data with...
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Nicoya redefines SPR with new affordable, benchtop 2-channel system
Nicoya releases their new 2-channel OpenSPR instrument. With the addition of a second channel and a ...
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SPR, ITC, MST & BLI: What’s the optimal interaction technique for your research?
Currently, the four most used techniques are Surface Plasmon Resonance (SPR), Isothermal Titration C...
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How Dr. Piazza uses SPR to complement NMR data for protein structure-function publications
Dr. Piazza, PhD graduate from the University of Waterloo, uses both NMR & OpenSPR’s surface plasmo...
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8 Ways to Make The Most Of Your Leftover Research Funding
As the fiscal year end quickly approaches, we understand how hard it is to juggle purchasing lab equ...
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SPR Binding Data Advances Muscular Dystrophy Research
Are you missing quantitative binding data data in your publication? Dr. Rossi, a collaborative resea...
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SPR Expert Interview: Dr. George Espie
Meet SPR Expert: Dr. George Espie. Dr. Espie is a Professor of Biology at the University of Toronto ...
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Waterloo Professor Thorsten Dieckmann Says SPR Data Was Key Link Needed For Publication
Dr. Dieckmann, Mike Piazza and Dr. Guillemette from the University of Waterloo published a paper tha...
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Comparison Study of SPR Instruments Using Commercially Relevant Binding Systems
Comparison Study of SPR Instruments Using Commercially Relevant Binding Systems: A protein-protein i...
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Binding Kinetics of Protein-Lipid Interactions Using Surface Plasmon Resonance
Surface plasmon resonance (SPR) can be used to analyze all types of interactions ranging from protei...
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8 Advantages of Using SPR in Your Own Lab
What do you do if you need a specific piece of equipment, but can’t afford to purchase it outright...
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Binding kinetics of glycoprotein interactions using surface plasmon resonance
Surface plasmon resonance (SPR) can be used to analyze all types of interactions ranging from protei...
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SPR Expert Interview: Dr. Thorsten Dieckmann
Dr. Thorsten Dieckmann, University of Waterloo Associate Professor in Chemistry and Biochemistry, ha...
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Nicoya’s Q & A: Researcher Profile – Dr. Guy Guillemette
Dr. Guy Guillemette, University of Waterloo Associate Professor in Chemistry and Biochemistry, has u...
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Binding Kinetics of Aptamer Interactions Using Surface Plasmon Resonance
Surface plasmon resonance (SPR) can be used to analyze all types of interactions ranging from protei...
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A Simple Guide to Choosing the Best Ligand for Your SPR Experiment
Binding and affinity data are key for characterizing molecular interactions, and with benchtop SPR, ...
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Meet the world’s youngest benchtop SPR user: 17-Year-Old Eric Wang
As life science researchers, we all understand the importance of obtaining reliable, consistent bind...
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Nicoya Hires Senior Sales and Marketing Executive Jim Harp to Drive Global Expansion
Nicoya recently hired Jim Harp to serve as their VP of Business Development. Nicoya is looking to fu...
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Why Every Biochemistry Teaching Lab Needs SPR Technology
SPR is a gold standard technique used in the biotechnology industry to measure binding kinetics and ...
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Automated Surface Plasmon Resonance Levels the Playing Field in Protein Science
On January 20, we announced our newest product, OpenSPR-XT – a fully automated molecular analysis ...
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6 Advantages of Surface Plasmon Resonance Technology
Surface plasmon resonance (SPR) has been around for more than 20 years, yet many researchers still r...
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Discover Why RNA Interactions and Binding Kinetics Matter
Using SPR for RNA Binding Kinetics at Rustbelt Meeting 2015 We recently attended the wonderful Rustb...
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Antibodies
Outcomes: Determine kon and koff (kinetics) and KD (affinity) values Quantify le...
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How to Become a Surface Plasmon Resonance Superhero: Top 5 Things We Learned at SensorCon 2015
SensorCon One was a 4 day intensive training course/conference hosted in Salt Lake City, UT by David...
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What We Learned at ASV 2015
We recently attended the 34th Annual Meeting of the American Society for Virology (ASV 2015) at the ...
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Welcome to Nicoya Lifesciences
Hello everyone, Scientists should have powerful instrumentation in their own labs, on their own benc...