Digitalized label-free assays for
transmembrane protein binding
The digital, label-free solution for
screening biologics
Redefine your workflow with Digital SPR.
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We partnered with ACROBiosystems, leading developer of recombinant proteins, to characterize a cancer-associated transmembrane protein.
Many human diseases are known to be associated with transmembrane proteins (TPs), making them ideal candidates for drug development. Multi-pass transmembrane proteins are not stable outside of the cell membrane environment, and are therefore difficult to purify and to express in large quantities. This has resulted in the under-characterization of a critical group of biomolecules.
One strategy for overcoming these challenges is to use vectors that closely mimic cell membranes, such as nanodiscs. In this application note, Alto Digital SPR was used to characterize binding kinetics of claudin-18.2 in nanodiscs from ACROBiosystems. Learn how Alto:
Characterizes a wide dynamic range of affinities & kinetics.
Automates assays to reduce hands-on time and user variation.
Reduces sample consumption by up to 200X.
Simplifies set up and analysis to accelerate time to results.
