Evaluate antibody diversity with digital surface plasmon resonance.

Make discoveries, not compromises. Learn more about Alto today.

The digital, label-free solution for antibody characterization

The digital, label-free solution for 
screening biologics

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Redefine your workflow with Alto

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APPLICATION NOTE

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Epitope characterization of influenza antiviral targets with Alto™

Galvanize your productivity by 
reducing the cost and effort of your biotherapeutics projects. 

Characterizing the binding kinetics and epitope diversity of various antibodies to viral antigens is essential for treating and preventing potential outbreaks. In collaboration with Sino Biological, a global leader in recombinant technology, we use Alto to perform kinetic analysis and epitope characterization of several antibodies against Influenza A hemagglutinin (HA).

Read our latest application note to learn how Alto: 

  • Analyzes 256 pairwise binding interactions on a single cartridge in a 16 x 16 format. 

  • Requires <100 ng per antibody and ~1 μg of antigen.

  • Performs self-referencing of solution mAb to surface.

  • Goes from sample prep to analysis in less than 16 hours.

Crude sample compatibility, low sample volumes, automated assays, and cloud-first software help you take the guesswork out of binding analysis and simplify your research. 

Powered by digital microfluidics, Alto™ revolutionizes real-time SPR interaction analysis by eliminating the need to compromise on quality and time. By collapsing 16x16 epitope binning runs into pre-designed, automated assays, Alto reduces the cost and complexity of antibody discovery. 

Meet Alto™ 

Low sample consumption
Simultaneously analyze 256 unique interactions using <100 ng of antibody and 1 μg of antigen.
One-click data analysis
Power your biotherapeutics projects with Alto's one-click analysis to galvanize productivity. 
Automated assays
Collapse 16x16 epitope binning runs into pre-designed, automated assays that reduce time, effort, and cost.