Resources
OpenSPR Brochure
OpenSPR brings reliable, label-free SPR measurements to a compact benchtop format, enabling first-pass interaction validation and structure–function exploration.
OpenSPR
Exploring Molecular Interactions with OpenSPR: A Perspective from the Johal Lab
We recently talked to Professor Malkiat S. Johal, a Professor of Physical Chemistry at Pomona College, about his experience using Nicoya’s OpenSPR. Hear more about…
Researcher Spotlight: Uncovering the molecular mechanisms of muscle function using OpenSPR
Learn about how OpenSPR user Sabrina Apel employs Nicoya’s SPR technology to study protein-protein interactions that regulate muscle function. Sabrina Apel is a PhD candidate…
From bench to publication: How OpenSPR® has galvanized label-free studies of diseases across the globe
Explore how OpenSPR is advancing disease research in over 200 peer-reviewed publications Affordability and ease of use have made OpenSPR® a powerful tool in labs…
Regeneration of His-tagged Streptavidin on OpenSPR® NTA Sensors Sensors
Overview Capture coupling techniques are advantageous to investigate biomolecular interactions as they provide specificity for immobilization on the OpenSPR real-time, label-free biosensor platform. Streptavidin sensors…
Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022
Hanson, E.K.; Whelan, R.J. Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022. Sensors. 2023, 23, 4831. https://doi.org/10.3390/s23104831…
Binding Kinetics of Complementary Oligonucleotide Sequences using OpenSPR™
Overview Oligonucleotides are an important area of biotechnological and pharmaceutical research, as demonstrated by the recent success of mRNA-based COVID-19 vaccines. Oligonucleotides, namely siRNA and…
Epitope Characterization of Influenza Targets using OpenSPR™
Overview Rapid changes in influenza antiviral target proteins due to antigenic drift result in cloaking of the influenza virus from the immune system of vaccinated…
OpenSPR Binding Data Reveals a Potential Mechanism for the Treatment of Depression
Introduction Depression is becoming more and more common worldwide, with approximately 1 in 30 people being affected by the illness[1]. Resulting from a combination of…
OpenSPR Binding Data Reveals a Potential Mechanism for the Treatment of Depression
Introduction Depression is becoming more and more common worldwide, with approximately 1 in 30 people being affected by the illness1. Resulting from a combination of…
Application Note: Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain using OpenSPR-XT™
High-affinity SARS-CoV-2 antibody characterized using Surface Plasmon Resonance (SPR). Finding a Solution to COVID-19 Together Widely considered the largest public-health emergency of the last century,…
Binding of SARS-CoV-2 Antibody to the Spike Protein Receptor Binding Domain Using OpenSPR-XT™
Overview The analysis of binding kinetics with SPR plays a critical role in the understanding of COVID-19. This includes basic research for understanding the viral…
App Note: Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Virus-like particles (VLPs) are complex molecules composed of multiple protein subunits that resemble a specific virus without its genetic material. VLPs allow researchers to safely…
Binding Kinetics of a Virus-Like Particle using OpenSPR-XT™
Overview Virus-like particles (VLPs) are complex molecules composed of multiple subunits that resemble a specific virus without its genetic material. VLPs are frequently used to…
App Note: Binding Kinetics of an Antibody Serum Sample Using OpenSPR™
You asked. We answered. Our team at Nicoya speaks with hundreds of researchers every week. We regularly hear that researchers want to perform kinetic analysis…
Binding Kinetics of an Antibody Serum Sample Using OpenSPR™
A common application of the SPR technique is antibody screening, which is critical to the development of vaccines and other immunotherapies. Since this development often…
New Publication – OpenSPR™ Binding Data Reveals Novel Mechanisms of Alzheimer’s Disease
Over 50 million people worldwide have been diagnosed with Alzheimer’s Disease (AD) or another form of dementia, according to the World Alzheimer Report 2018 (Patterson,…
